A calmer mood starts in your gut.
When your gut is out of balance, your mood, clarity, and ability to handle stress can be too. Mood Balance combines clinically studied Postbiotics and botanicals to support gut health and the gut-brain axis - so you can feel calmer, clearer, and more like yourself again with steady, consistent daily results.
Clinically Studied Ingredients
Postbiotic-first formula for gut + mood support
No Live Bacteria
Postbiotics are the real outcome you wanted in the first place.
The fertilizer.
Fibers that feed bacteria, but rarely work if the right microbes aren't present.
The seed.
Live bacteria you try to add, but fragile, inconsistent, and often don’t survive digestion.
The harvest.
Trillions of beneficial compounds your body actually needs, ready to work, stable, fast, and effective.
Bereum, used in SecondKind’s Gut Balance and Mood Balance, promotes the production of SCFAs to optimize microbiome balance. This fundamental support strengthens physical health and helps manage stress, offering results you can actually feel. It's why I recommend SecondKind.
— Dr. Hyun Dong Shin, Ph.D., Independent Microbiologist & Postbiotic Expert
By centering its formulas around postbiotics, SecondKind is translating the latest gut-brain research into something accessible for consumers. It reflects a more modern, science-forward understanding of digestive health.
— Dr. Stuart Weinberger, MD, Gastroenterologist
Gut health isn’t a niche topic anymore - it’s whole-body health, rooted in neuroscience and immunology. In clinical research, postbiotics are emerging as a direct, bioavailable way to influence gut health and systemic balance.
— Dr. Zachary Schwartz, MD, Family Medicine
As a holistic nutritionist, I’ve seen countless gut supplements offer fake promises and deliver nothing…. ineffective results. SecondKind stands apart because it’s postbiotic-first - finally, a solution that aligns with what the science tells us the body truly needs.
— Dr. Nancy Lin, PhD, Holistic Nutritionist
Daily support for a calmer mood, clearer mind, healthier gut, and more balanced days. Mood Balance is a better way to get consistent gut health, clarity, and calm.
→ Supports mood balance, relaxation & emotional well-being*
→ Helps ease occasional stress and promotes calm*
→ Supports a healthier gut and balanced gut-brain connection*
→ Supports mental clarity, focus & a more uplifted mood*
→ Clinically studied postbiotics, not live bacteria
Your gut and brain are deeply connected through what science calls the gut-brain axis, a two-way superhighway that influences how you think, feel, and function. When this connection is out of sync, it can affect mood, focus, sleep, and even your ability to handle stress.
Mood Balance works at the source. Our BiomeBalance™ complex uses clinically studied Postbiotics to help restore healthy signaling between your gut and brain. This supports serotonin production, reduces stress responses, and promotes calm focus from within.
Paired with saffron extract, shown in studies to support emotional wellbeing, Mood Balance helps you feel lighter, more relaxed, and emotionally balanced, all through the power of your second brain.
Discover why your gut is the hidden system shaping your mood, immunity, clarity, and energy - and why postbiotics are the key to feeling like yourself again.
• Digestion starts to feel lighter and more predictable.
• You feel more “even” day-to-day - fewer dips, smoother energy.
• Your gut environment is shifting toward balance, helping your body respond better to stress and food.*
• Energy feels grounded, not up-and-down.
• Bloating continues to ease; your gut rhythm feels more natural.
• Everyday resilience strengthens - you bounce back from busy days more easily.
• Foods that used to bother you feel easier to handle.*
• Your microbiome becomes more stable, even if your schedule or diet gets messy.
• You feel clearer, lighter, and more consistently energized.
• Low-grade inflammation eases, supporting better clarity and vitality.*
• Your gut, brain, and immune system work together smoothly.
• Comfort becomes your new baseline - not something you have to chase.*
• Wellness feels easier and more automatic, supported by ongoing use.
Feel balanced, uplifted, and emotionally steady.
Ease everyday stress and anxiety from within.
Balanced energy without spikes or crashes.
Most wellness products focus on adding bacteria, also known as probiotics. But your body doesn’t use the bacteria themselves. It uses the healthy metabolites they produce. These are bioactive compounds your body can actually use. That’s what Postbiotics are. They skip the middleman by delivering the benefits directly, even when prebiotics and probiotics might not survive digestion. The end result of healthy gut activity.
Prebiotics feed bacteria, probiotics are bacteria, but Postbiotics are what your body actually needs and uses right away.
*Some prebiotics (via short-chain fatty acids) and certain probiotic strains may also support gut lining, but postbiotics provide the most direct and consistent benefit.
| Category | 
(the harvest) |
Probiotics (the seeds) |
Prebiotics (the fertilizer) |
|---|---|---|---|
| Stress Relief | |||
| Body-Ready & Usability | |||
| Digestive Comfort | |||
| Immunity | |||
| Mind & Mood | |||
| Fast-Acting | |||
| Shelf-Stable | |||
| Whole-Body Wellness | |||
| Gut-Lining Support | * | * | |
| Potency |
(Trillion)
|
(Billion) |
*Some prebiotics (via short-chain fatty acids) and certain probiotic strains may also support gut lining, but postbiotics provide the most direct and consistent benefit.
Patented, clinically studied blend delivering trillions of bioactives. It took years of research to develop the right combination and clinical dosing of Postbiotics that actually work. Designed to work fast to support your second brain for clarity, calm, and resilience.
Our Clinically Studied Postbiotics
BiomeBalance uses patented, research-backed postbiotics like Totipro®, EpiCor®, and Bereum® - fermentation-derived compounds your body can use right away.
✓ Each one is shelf-stable, clinically validated, and precisely formulated.
→ Calms digestive distress, supports immune defenses, and promotes a balanced microbiome.
→ Clinically studied Totipro® supported bowel regularity in 30 days and promoted beneficial gut bacteria. Source: Kuo et al.,Lin et al., Journal of Pure and Applied Microbiology (2022)
→ Clinically shown to relieve bloating and gut discomfort, ideal for daily gut balance or travel relief.
→ A whole-food fermentate packed with metabolites that strengthen gut lining, boost resilience, and help you stay well year-round.
→EpiCor® was shown to reduce cold and flu symptom days by 17% in a 12-week randomized, placebo-controlled trial. Source: Moyad et al., Urologic Nursing (2008)
→ Clinically shown to reduce bloating, improve gut comfort, and deliver fast, noticeable digestive relief.
→ Help regulate mood and gut-brain signaling, supports emotional balance through the gut.
→ Clinically studied Bereum postbiotics significantly improved gastrointestinal symptoms, perceived stress, and digestive-related quality of life, in an 84 day study. Source: bereum Human Clinical Study Summary for beLP1® and EF-2001®
Mood Balance is a Postbiotic-first supplement formulated with BiomeBalance™ plus clinically studied botanicals like lemon balm, saffron, and passionflower to support stress resilience, mood balance, and mental clarity. Because a healthier gut plays a powerful role in how you feel day to day, it’s designed to support the gut-brain connection as a foundation for calmer moods, clearer thinking, and overall well-being.
Most gut supplements rely on live bacteria (probiotics) that may or may not survive your stomach acid.
Postbiotics are different. They’re the beneficial compounds your gut bacteria produce - already active, already usable - so your body gets the benefit immediately, without waiting for bacteria to colonize or survive.
Think of it as skipping the middleman - and getting results faster.
In more depth: Postbiotics are the beneficial compounds your gut produces when probiotics (good bacteria) ferment prebiotics (fibers and plant compounds). Think of them as the active nutrients your body can immediately use - such as short-chain fatty acids, peptides, and enzymes .
Here’s what makes them extraordinary: while probiotics usually deliver billions of live bacteria, postbiotics represent the trillions of bioactive metabolites those microbes create. These are the actual compounds your body uses to strengthen digestion, immunity, mood, and focus.
Postbiotics also help your gut communicate with the rest of your body:
In short: postbiotics aren’t just about digestion - they’re about whole-body balance. You don't have to believe they'll work - just notice how you feel.
Yes - our products are made with clinically studied postbiotic ingredients, including ingredients backed by human clinical studies, and held to high standards for quality and consistency, including third-party testing. We also provide Certificates of Analysis to help give you added confidence in the quality of what you’re taking. We believe trust comes from combining rigorous quality with real science - not hype.
To explore the research and learn more about the science behind our formulas, visit our Science Page.
Mood Balance:
• Supports balanced, uplifted mood*
• Helps ease stress and promotes calm*
• Supports emotional balance and daily resilience*
• Supports the gut-brain connection for mood and clarity*
• Powered by clinically studied postbiotics for mood, gut, and whole-body balance
Supplement Facts Serving Size: 1 Capsule (1-2 times a day); 60 Servings Per Container:
BiomeBalance Postbiotic Complex 50mg [Soy Protein, Glucose, Saccharomyces cerevisiae,
Lactobacillus plantarum, Lactobacillus salivarius, Bifidobacterium infantis, Lactobacillus acidophilus,
Enterococcus faecalis]
Lemon Balm (Aerial Parts) – 350 mg (†)
Passionflower 4:1 Extract (Whole Plant) – 35 mg (†)
Saffron Flower Extract (0.3% Safranal) – 15 mg (†)
Melatonin – 5 mg (†)
Vitamin B6 (as Pyridoxine HCl) – 10 mg (588% DV)
Folate (as 400 mcg Folic Acid) – 680 mcg DFE (170% DV)
Magnesium (as Magnesium Hydroxide) – 100 mg (24% DV)
(†) Daily Value (DV) not established.
Other Ingredients: Hypromellose (Capsule), Microcrystalline Cellulose, Magnesium Stearate, Silicon
Built on the mood-regulating benefits of BiomeBalance™, Mood Balance combines science-backed postbiotics, with calming botanicals that work in harmony to support emotional wellbeing and focus.
Unlike probiotics, which rely on live bacteria that may not survive the gut, Mood Balance delivers postbiotics—bioactive compounds your body can use immediately, with fast-acting effects on gut-brain health.
Most people feel a shift in mood or clarity within days and weeks, not months, thanks to the “Feel It Fast” formula that combines postbiotics with calming botanicals.
Week 1: Early ease - less bloating and digestive tension.
Weeks 2–3: Energy steadies, clarity lifts, and your gut rhythm begins to balance.
Month 1–2: Mood, focus, and immune balance feel more predictable.
Month 3+: Long-term harmony - gut, brain, and body in sync, for whole body health.
(Consistent daily use builds lasting gut resilience.)
Take 1 capsule, 1–2 times daily, ideally in the evening to align with your body’s natural relaxation rhythms.
Mood Balance is designed for consistent, daily use and formulated with clinically studied postbiotic compounds that support the gut–brain connection.
Because postbiotics aren’t live bacteria, they’re stable, gentle, and well-tolerated - making them suitable for everyday support.
Every batch is third-party tested for quality and purity, and our ingredients are selected based on clinical research - not trends.
As with any supplement, we recommend consulting your healthcare provider if you’re pregnant, breastfeeding, managing a medical condition.
Yes. It is vegan, non-GMO, and free from gluten, artificial colors/flavors, sucrose, starch, wheat, corn, gelatin, and nuts. It does contain soy.
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